A.A. di erogazione 2016/2017

 (A.A. 2015/2016)
Anno di corso: 
Tipologia di insegnamento: 
Settore disciplinare: 
Primo Semestre
Ore di attivita' frontale: 
Dettaglio ore: 
Lezione (48 ore)

Knowledge and understanding (Knowledge and know)
After the course the student should be endowed with a comprehensive knowledge of immunopathology and cancer immunology

Applying knowledge and understanding (Skills and know how)
Since the course does not encompass the solution of exercises or problems, student’ s applying knowledge will be evaluated through his/her capability to critically discuss and design experimental approaches in immunopathology and cancer immunology

In order to attend profitably the lessons, the student should be endowed with basic notions in immunology

General Immunopathology
Immune regulatory circuits:
a)TH1,TH2,TH17 and Treg
b) peripheral tolerance and Immune checkpoints
c) danger Theory and Damage Associated Molecular Patterns (DAMPs)
The mucose immune system and its interaction with gut microbiota
Inflammation and metabolism
Immune hypersensitivity
a)IgE-mediated allergy sensitization and effector mechanisms
b)non-IgE mediated hypersensitivity, types II-IV
a)breaking of self tolerance
b)pathogenic mechanisms of autoimmune diseases
c)genetic and environmental basis of autoimmunity
d)examples of autoimmune diseases

Immunology of cancer
Chronic inflammation and cancer / tumor microenvironment
-morphological evidences
-epidemiological evidences
-functional and experimental evidences
b)main cells in tumor stroma
Immunotherapy of cancer
a) immunosurveillance and immunoediting
b) evasion by cancer cells from immune detection
c)principal strategies for immunotherapy of cancer
-therapeutic cancer vaccines
-monoclonal humanized antibodies
-checkpoint inhibitors
Other aspects related to immune response for a whole organism view of cancer
a)Warburg effect and cancer metabolism
b)cancer cachexia

The course consists of lectures (4 CFU).

The exam consists of two sections: in the multiple choice test the teacher broadly verifies the factual knowledge of the subject, in the oral examination the teacher evaluates the understanding of the subject and the critical discussion skills of the student

immunopathology section:

Kenneth Murphy, Casey Weaver Janeway’s immunobiology Garland Sciences
Peter Parham The immune system Garland Sciences

Immunology of cancer section:

Robert Weinberg The biology of cancer Garland Sciences
reviews or original papers on the subject and lecture’s files provided by the teacher on the e-learning platform

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A.A. 2018/2019

Anno di corso: 2
Curriculum: Oncology

A.A. 2017/2018

Anno di corso: 2
Curriculum: Oncology

A.A. 2016/2017

Anno di corso: 2
Curriculum: Oncology