ABT - Module II: Stem Cells

A.A. di erogazione 2016/2017
Insegnamento obbligatorio

 (A.A. 2015/2016)

Docenti

L'insegnamento è condiviso, tecnicamente "mutuato" con altri corsi di laurea, consultare il dettaglio nella sezione Mutuazioni
Anno di corso: 
2
Tipologia di insegnamento: 
Caratterizzante
Settore disciplinare: 
BIOLOGIA APPLICATA (BIO/13)
Attivita' formativa capogruppo: 
Crediti: 
4
Ciclo: 
Primo Semestre
Ore di attivita' frontale: 
32
Dettaglio ore: 
Lezione (32 ore)

The aim of this course is to provide the student with an updated knowledge about:
Cell Cycle
Apoptosis
Growth Factors Receptors
Toll-Like Receptors
Embryonic Stem Cells
Adult Stem Cells
Induced Pluripotent Stem Cells (iPS)

A solid background in: Biochemistry and Molecular Biology, Cell Biology.

Cell Cycle
Phases of the cell cycle
Check points and regulations
Cyclines
Cdk
Apoptosis
Intrinsic pathway of apoptosis
Extrinsic pathway apoptosis
Receptors involved in apoptosis
Role of Cytocrome C
Pro- and anti-apoptotic proteins
Caspase cascade
 
Growth Factors Receptors
 
Receptors with intrinsic kinase activity
SH2 domain
Death domain
Intracellular signaling and adaptor proteins
MAP Kinases pathway
Myc
Toll-Like Receptors
Receptors structure
DAMPS
PAMPS
Intracellular signaling
MyD-88 pathway
NF-kB
AP-1
 
Embryonic  Stem Cells
General characteristics
 
Adult Stem Cells
General characteristics
 
Induced Pluripotent Stem Cells (iPS)
General characteristica
OCT
Sox
Klf
Myc
Methods to verify totipotency
Some applications of the iPS

The course consists in ex cathedra lectures, with the main purpose of creating a direct interaction with students, in order to encourage students to find interests in the topics of the course.

The learning outcomes will be assessed by an oral interview (of about 30 minutes length) on any topic selected from the syllabus.
 

Materials will be provided at the beginning of the course, which consists mainly of slides and videos in order to complete the oral part of the lesson.

Prof. Rossetti will receive the students in his office in Varese (Via Dunant 3); in order to meet the professor, students will have to schedule appointments by e-mail (carlo.rossetti@uninsubria.it). During the course, he also will be available for 30 minutes after each lecture.