CELLULAR AND MOLECULAR ONCOLOGY

A.A. di erogazione 2020/2021
Insegnamento opzionale

Laurea Magistrale in BIOMEDICAL SCIENCES
 (A.A. 2020/2021)
Anno di corso: 
1
Tipologia di insegnamento: 
Affine/Integrativa
Settore disciplinare: 
BIOLOGIA APPLICATA (BIO/13)
Lingua: 
Inglese
Crediti: 
6
Ciclo: 
Secondo Semestre
Ore di attivita' frontale: 
48
Dettaglio ore: 
Lezione (40 ore), Seminario (8 ore)

The aim of the course is to introduce the students to the biological and molecular aspects of neoplastic transformation and to explore how these mechanisms are altered in different types of cancer. Emphasis will be given to the events that drive cancer initiation, cancer progression and metastatic dissemination. The role of the micro-environment will also be deeply investigated, now considered to be a key player in supporting all phases of the development of cancer.

At the end of the course, the students will:
 get to know the fundaments of molecular mechanism of cancer onset, progression and metastasis
 describe the reciprocal relationship between the microenvironment and tumour cells
 distinguish the role of cancer stem cells from the bulk tumour cells
 return the complexity of the epigenetic processes involved in tumour progression
 build conceptual maps for the explanation of the still unresolved aspects of genetic and epigenetic hierarchy during tumour onset and progression
 search PubMed for the relevant scientific articles for their exam
This course will also provide the students with the opportunity to develop as adult learners and as effective contributors in a professional environment by:
1. Being responsible for their own learning and for the depth of their own study.
2. Using their own initiative to make use of all the available resources to complement lecture material, including academic staff resources.
3. Working in a team environment and contributing effectively to their own learning and to that of their peers by questioning each other and academic staff when uncertain.
4. Developing communication skills by effective interaction with peers and academic staff.

The optional Cellular and Molecular Oncology course is part of the two curricula (Basic and Applied Biomedical Sciences and Double Degree) of the first year of the Master's Degree in Biomedical sciences, allowing the student to study in depth cellular and molecular bases that govern pathological processes in oncology

In order to follow the course, an adequate knowledge of cell and molecular biology, biochemistry and physiology is required.

Through lectures, students will investigate, in the first part of the course, how recent advanced techniques have improved the knowledge of the main pathways related to the biology of cancer processes and some neurodegenerative diseases, taken as examples. A section of the course will focus on the theoretical aspects of the use of these techniques for preventive medicine, with particular reference to environmental molecular epidemiology.
In the second part, the students will learn the biology of embryonic and adult stem cells and their capacity to self-renew and to generate multiple mature cell types, and their therapeutic potential.

The course topics will be dealt with lectures-style instruction with the use of electronic presentations.
Each lesson will be subdivided in three rounds of 50min each, two breaks of 10min and 15 minutes of discussion with the students on the topics covered, for a total of three hours.
Working groups will be organized on specific issues related to the course topics.

Oral exams. For the exam, the student will prepare a presentation on one of the topics discussed during the course. The students will be provided with a list of specific topics, among which they will chose one for the preparation of a presentation. Updated reviews and research articles for the presentation will be provided on each topic. The students will need to further search on PubMed for additional research articles on the topic of interest to personalise their presentation.
The students need to demonstrate:
 sufficient knowledge of the specific topic presented
 the ability to discuss cutting edge molecular techniques
 the correct use of scientific terms
 to be able to make connections between the topics covered during the course and those not included in the presentation
To pass the exam, the student needs to get a score of at least 18/30

Oral exams. For the exam, the student will prepare a presentation on one of the topics discussed during the course. The students will be provided with a list of specific topics, among which they will chose one for the preparation of a presentation. Updated reviews and research articles for the presentation will be provided on each topic. The students will need to further search on PubMed for additional research articles on the topic of interest to personalise their presentation.
The presentation will be prepared on the basis of the material provided and of the further articles the students will have retrieved from PubMed and must not be longer than 40 min, 15 min of discussion will follow.
The students need to demonstrate:
 sufficient knowledge of the specific topic presented
 the ability to discuss cutting edge cellular and molecular aspect of oncology
 the correct use of scientific terms
 to be able to make connections between the topics covered during the course and those not included in the presentation

The teacher receives the students after each lesson and by appointment.
https://www.uninsubria.it/hpp/ian-marc.bonapace
ian.bonapace@uninsubria.it

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A.A. 2019/2020

Anno di corso: 1
Curriculum: Basic and applied biomedical sciences