- Scheda dell'insegnamento
- Obiettivi formativi
- Metodi didattici
- Verifica dell'apprendimento
This course is intended to the understanding of the general principles, terminology, diagnostic procedures, and basic concepts of pathology and will introduce to the study of the structural, biochemical, and functional changes in cells, tissues, and organs that underlie disease and the various pathological processes and their importance in the basis of human disease will be studied.
In order to follow the course, an adequate knowledge of cell and molecular biology, biochemistry and physiology is required.
1) Brief history of the changing concept of disease in Western medical thought. Overview: Diagnosis and aetiology of disease; inherited versus acquired disorders, Cellular Responses to Stress and Noxious Stimuli. The body’s response to lethal and sub-lethal injury. Homeostasis and adaptive response to injury.
2) Cellular Responses to Stress and Toxic Insults: Adaptation, Injury, and Death. Adaptations of Cellular Growth and Differentiation. Hypertrophy, Hyperplasia, Atrophy, Metaplasia. Cell Injury and Cell Death. Causes of Cell Injury, Morphologic Alterations in Cell Injury, Reversible injury, Necrosis. Mechanism of cell injury. Clinico-Pathologic Correlations: Selected Examples of Cell Injury and Necrosis. Ischemic and Hypoxic Injury, Chemical (Toxic) Injury. Apoptosis. Autophagy. Cellular aging and senescence
3) Intracellular accumulations and calcifications. Lipids, Proteins, Hyaline change, Glycogen, Pigments. Pathological calcifications, dystrophic and metastatic calcifications
4) Acute and Chronic Inflammation. Acute Inflammation, Mediators of Inflammation, Outcome of Acute Inflammation, Morphologic Patterns of Acute Inflammation. Chronic Inflammation, Systemic effects of Inflammation, Consequences of Defective or excessive Inflammation.
5) Tissue renewal, regeneration and repair. Control of Normal Cell Proliferation and Tissue Growth, Cell Cycle and the Regulation of Cell Replication, Mechanisms of Tissue and Organ Regeneration, Extracellular Matrix and Cell-Matrix Interactions, Healing by Repair, Scar Formation and Fibrosis (inflammation, angiogenesis, migration and proliferation of fibroblasts, scar formation connective tissue remodelling).
6) Hemodynamic Disorders, Thromboembolic Disease, and Shock. Edema, Hyperemia and congestion, haemorrhage, Homeostasis and thrombosis, Embolism, Infarction, shock
7) Genetic disorders. Mendelian disorders, Complex multigenic disorders, chromosomal disorders, Single-gene disorders with non-classic inheritance.
8) Infectious disease. Categories of Infectious Agents. Transmission and Dissemination of Microbes. How Microorganisms Cause Disease. Immune Evasion by Microbes. Infections in Immunosuppressed Hosts. Spectrum of Inflammatory Responses to Infection.
The course topics will be dealt with through lectures-style instruction. Working groups will be organized on specific issues related to the course topics, on which the students will have to prepare an assay and a presentation.
Oral exames. To pass the exam, the student will need to demonstrate sufficient knowledge of the topics covered in class to pass the exam.
Authors: Vinay Kumar & Abul K. Abbas & Jon C. Aster
Title: Robbins & Cotran Pathologic Basis of Disease, 9th Edition. Elsevier
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