Università degli studi dell'Insubria

PHYSIOPATHOLOGY OF THE CNS

A.A. di erogazione 2017/2018
Insegnamento obbligatorio

Docenti
FESCE RICCARDO GIUSEPPE
Anno di corso: 
1
Tipologia di insegnamento: 
Caratterizzante
Settore disciplinare: 
FISIOLOGIA (BIO/09)
Crediti: 
6
Ciclo: 
Secondo Semestre
Ore di attivita' frontale: 
48
Dettaglio ore: 
Lezione (48 ore)

-- Understanding the functional organization of the Central Nervous system
-- Understanding how the molecular and cellular processes in neurons and glia and the organization of neural circuits give rise to sensory information processing, motor control, sleep, memory, learning, emotions, language, thought and motivated behaviour
-- Understanding how genetic, environmental factors and psychological experience may interact in generating neurological and psychic disturbances
-- Knowing the main features of the most important CNS pathologies (Parkinson's, Huntington's, Alzheimer's diseases, epilepsy and migraine, ALS, Schizophrenia, Bipolar Spectrum Disorders, Autistic Spectrum Disorders, ADHD)
-- Identify the main paths and approaches for research in Neuroscience and understand the specificities of diagnostic, monitoring, symptomatic and disease-modifying strategies and approaches
-- Capacity to identify how a genetic alteration, an environmental factor or the impairment of a cellular function may interfere with the normal functioning of cerebral circuits and give rise to neurological or psychic derangement
-- Capacity to illustrate the specific features of Central Nervous System pathophysiology, of the neuron-glia interaction, of the processes of neurodegeneration and of possible strategies of neuroprotection
-- Capacity to describe and explain the modalities of onset of a neuropathological picture

Prerequisiti: 

Good knowledge of physiology and Neurophysiology in particulat

NeuroPhysiology (18 h)
Functional organization of the Central Nervous System (CNS)
Synaptology
Neurotransmitters in the CNS
Neuromodulation and neural computing
Neuronal and synaptic plasticity
Neuronal development and degeneration. Glia and neurons
The organization of the cerebral cortex
Sensory system and central processing of sensory information
Motor control
Sensory and motor disturbances (12 h)
Multiple Sclerosis (MS)
Cerebellum physiopathology
Basal nuclei physiopathology
Amyotrophic Lateral Sclerosis (ALS)
Parkinson's Disease (PD)
Huntington's Disease (HD)
Physiopathology of memory and learning (4 h)
Alzheimer's Disease (AD)
The limbic system - Mood disturbances: Anxiety and Depression (BDS) (4 h)
Epilepsy and Migraine (2 h)
The neural basis of consciousness -- cognitive disturbances (8 h)
Autistic Spectrum Disorders (ASD) and Attention Deficit + Hyperactivity Disorder (ADHD)
Thought disturbances - Psychosis and Schizophrenia
The organization of higher functions – Language

Lectures

Modalita' di verifica dell'apprendimento: 

final oral exam where the students must demonstrate that (1) they are capable of explaining the pathogenesis of a chosen neuropathological condition and the related functional derangements; and (2) that they posses a general knowledge of the topics dealt with in the course

-- Principles of Neural Science E.R. Kandel, J.H. Schwartz, T.M. Jessel - McGraw Hill Professional, 2013
-- Fundamental Neuroscience, L.R. Squire, D. Berg, F.E. Bloom et al. - ELSEVIER, 4th ed., 2012

In addition to the slides, Relevant scientific articles can be accessed at the link of the University at Busto (ask the teacher for access)

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A.A. 2017/2018

Anno di corso: 1
Curriculum: Double Degree Programme

A.A. 2016/2017

Anno di corso: 1
Curriculum: Neuroscience
Anno di corso: 1
Curriculum: Double Degree Programme

A.A. 2015/2016

Anno di corso: 1
Curriculum: Neuroscience
Anno di corso: 1
Curriculum: Double Degree Programme