Università degli studi dell'Insubria

FASANO MAURO

foto di Fasano  Mauro

FASANO MAURO

Professori associati
Numero telefonico
0331 339 414,0331 339 423,0331 339 450

Mauro Fasano graduated in Chemistry in 1989 at the University of Torino working on NMR characterization of cell pigments. He later got the Doctorate degree (Chemical sciences, 1992) with a thesis on non-covalent interactions between small paramagnetic molecules and proteins. From 1992 to 2000 he was appointed to the position of Assistant Professor of general and inorganic chemistry at the Faculty of Sciences of the University of Torino. In the period 1992-2000 Prof. Fasano worked on the characterization of metal ion centers in biomolecules by NMR spectroscopy. In particular, he investigated the solid-state structure of different melanin pigments including human mesencephalic melanin, and the NMR relaxometric properties of heme proteins. These two interests have been further developed in the forthcoming years.
Starting from 1st November 2000 he has been appointed as an Associate Professor of Biochemistry at the Faculty of Sciences of the University of Insubria at Varese, being affiliated to the Department of Theoretical and Applied Sciences. He was among the founders of the University outstation in Busto Arsizio establishing there the laboratory of Neuroproteomics and contributing to the development of the Biomedical research division. His research interests are mainly devoted to two main areas: i) characterization of the allosteric properties of human serum albumin and ii) biochemistry of metabolic stress pathways in neurodegenerative diseases. The latter aspect, being the predominant one, is in turn focused on two main objectives: a) understand molecular mechanisms leading to neurodegeneration to eventually block them by neuroprotective drugs, and b) discover and validate peripheral markers of the disease to allow early and differential diagnosis so that neuroprotective or neurorestorative strategies could be attempted. Both objectives are mainly pursued by means of proteomics techniques, where a first look by a global, hypothesis-free approach is followed by a bioinformatic screening of functional information available in the literature to end up in the generation of a new hypothesis to be confirmed experimentally by classical, hypothesis driven methodologies.
He has been a member of the postgraduate school of molecular and cellular biology of the University of Insubria (2004-2008), and since 2008 he is a member of the Board of Advisors of the postgraduate school of Neurobiology of the University of Insubria. Since 1998 he collaborates with the Biotechnology Foundation (www.fobiotech.org) in the National School of Bioinformatics where he still has teaching duties. He has been among the founders of the first Master School in Bioinformatics in Italy (www.masterbioinformatica.it).
His long-standing record of project- and group-leader is witnessed by the following main activities:
1997-98: local unit coordinator, CNR target project on Biotechnologies.
1998-2008: coordinator of the biochemistry and proteomics unit at the Bioindustry Park Canavese, Colleretto Giacosa (Torino).
2002-04: principal investigator in the project "DAOS - danno ossidativo nella malattia di Parkinson" funded by Fondazione Monzino, Milano. Objective: To understand molecular mechanisms of Parkinson's disease using a cell model of dopamine toxicity.
2004-05: principal investigator in the project "Metabolic changes in the neurodegenerative process at the basis of Parkinson's disease" funded by the ministry of Health. Objective: To understand molecular mechanisms of Parkinson's disease pathogenesis by differential proteomic analysis of mesencephalic tissue specimens from Parkinson's disease patients.
2006: principal investigator of the project "SIMBA - Silicon Innovative Monitors for Biological Applications" supported by EU (Interreg IIIc) and Regione Lombardia. Specific aim: to develop new technological platforms for low cost and high performance analysis of antibody arrays for peripheral biomarkers quantification.
2008-2012: team leader in the identification of biomarkers of Parkinson's disease in peripheral blood cells. The project is currently supported by a lay association (Italian Parkinson's association).
2010-2012: industrial research project ParIS (Parkinson Informative Systems) funded by Regione Autonoma Valle d'Aosta through collaborative project agreement with BioDigitalValley Srl for the development of a software for automatic detection of biomarkers of Parkinson's disease in plasma.
2011-2013: team leader in the project "A cellular model for mitochondrial impairment in Parkinson's disease" funded by the Italian Ministry of University and Research.
Prof. Fasano has been past-president of the biological chemistry division of the Italian Chemical Society (2009-2011), member of the scientific board of the proteome chemistry group of the Italian Chemical Society (2009-2011), deputy-director of the Department of Structural and Functional Biology of the University of Insubria (2003-2011). He is currently coordinator of the biotechnology group of the Italian Chemical Society (2011-2013), deputy-director of the Center of NeuroScience of the University of Insubria (2009-2012), member of the scientific advisory board of the Italian Proteome Association (2010-2012 and 2013-2015). Moreover, he is member of the Italian League against Parkinson's Disease, of the Italian NMR Discussion Group, of the Human Proteome Organization and of the Italian Society of Biochemistry and Molecular Biology. He has been member of scientific committees of several national and international conferences including the World Chemistry Congress (Torino, 2007) as the scientific coordinator of the Biological Chemistry session.
He acted as reviewer for several journals in the fields of proteomics and neuroscience, such as Journal of Proteomics, Journal of Proteome Research, Proteomics, Proteome Science, Parkinsonism and Related Disorders, Biochimica et Biophysica Acta – Molecular Basis of Disease, Biochimica et Biophysica Acta – Proteins and Proteomics, FEBS Journal, Expert Reviews of Proteomics, Neuroscience Letters, Journal of Neurochemistry, Neurobiology of Aging, Neurobiology of Disease, Journal of Alzheimer's Disease, Future Neurology, Expert Reviews of Neurotherapeutics, Brain Research, Cell Research, Journal of Neuroscience, Scientific Reports.
He is author of about 125 papers on peer-reviewed international journals, as well as books, edited books, e-books, articles in encyclopedias. He received more than 3300 citations, with h-index = 29 (Sources: ISI Web of Knowledge and Scopus).

Anno Accademico: 2019/2020

Anno Accademico: 2018/2019

Anno Accademico: 2017/2018

Anno Accademico: 2016/2017

Anno Accademico: 2015/2016

Anno Accademico: 2014/2015

Anno Accademico: 2013/2014

Anno Accademico: 2012/2013