My research has been mainly focused on biophysics and bioenergetics of (at least, partially) self-assembling structures like viruses, chlorosomes (the main light-harvesting structures in green photosynthetic bacteria), microtubules and, more recently, has taken an historico-philosophical turn.
Going backwards in time, in fact, since 2009 I have been investigating overlapping genes in viruses addressing the problems of the biological significance and the evolution of this peculiar genetic arrangement in relation with viral genome size, the structure of the capsid and the energetic balance of the infected cell. I previously did also experimental work in virology studying the role of some bacteriophage T4 proteins involved in head and tail self-assembly and in the first steps of infection.
Since 1986 I have been conducting researches on both the regulatory and stress factor roles played by light in photosynthesis, studying both plants and photosynthetic bacteria, focusing in particular on the involvement of light harvesting complex II in plants and on chlorosomes in green bacteria.
At the beginning of my research career, as a university student (1983-1985) I have worked on the isolation, characterization and distribution of specific messenger RNAs (coding for alpha- and beta-tubulin, main constituents of microtubules) in the early phases of the embryo development of the animal model Xenopus laevisand their possible role in the early phases of neural tube development. .
As said above, the above mentioned researches are currently flanked by historical inquiries concerning either directly (the discovery of overlapping genes in the '70s of the last century) or indirectly (the interplay of physics and life sciences from the magmatic end of XVIII century to the XIX and XX century) my present and past research themes. A common theme is the development of two main research traditions in the life sciences, centered on metabolism and reproduction/heredity respectively. A privilegede point of view is the analysis of the information flux between the scientists "working on the bench and communicating to each other, to the one, if any, from them to the public. As a case study, I am presently focusing on the controversies over different theories on the origins of cancer.
Pubblicazioni in evidenza
Pavesi, A., Chirico, N., A.Vianelli, Belshaw, R., Firth, A., Bao, Y., Blinkova, O. and Karlin, D. (2017) Overlapping genes and the proteins they encode differ significantly in their sequence composition from non-overlapping genes (submitted)
Cannone, N., T.Corinti, F.Malfasi, P.Gerola, A.Vianelli, I .Vanetti, S.Zaccara, P.Convey, M.Guglielmin (2017) Moss survival through in situ cryptobiosis after six centuries of glacier burial. Sci. Rep. 7, 4438.
Ronchini, M., L.Cherchi, S.Cantamessa M.Lanfranchi, P.D.Gerola, G.Berta and A.Fumagalli (2015) Palladium uptake by Pisum sativum: partitioning and effects on growth and reproduction. Environ.Sci.Pollut.Res.Int. 22: 7600-7611.
Chirico, N., A.Vianelli, R.Belshaw (2010). Why genes overlap in viruses. Proc. Roy. Soc. B (Biol. Sci.) 277: 3809-3817.
Fior, S., A. Vianelli and P.D.Gerola (2009). A novel method for fluorometric continuous measurement of Beta-glucuronidase (GUS) activity using 4-methyl-umbelliferyl-beta-D-glucuronide (MUG) as substrate. Plant Sci. 176:130-135.
Pierce, S., B.Cerabolini and A.Vianelli (2005) From ancient genes to modern communities: the cellular stress response and the evolution of plant strategies. Functional Ecology 19: 763-776.
Cseh, Z., A.Vianelli, S.Rajagopal, S.Krumova, L.Kovacs, V.Barzda, R.Jennings ans G.Garab (2005) Thermo-optically induced reorganizations in the main light harvesting antenna of plants. I .Non-Arrhenius type of temperature dependence and linear light-intensity dependencies. Photosynth. Res. 86:263-273.
Di Valentin, M., D.Malorni, A.L.Maniero, G.Agostini, G.Giacometti, A.Vianelli, A.G.Cattaneo, L.-C.Brunel and D.Carbonera (2002) Structural investigation of oxidized chlorosomes from green bacteria using multifrequency Electron Paramagnetic Resonance up to 330 GHz. Photosynth.Res. 71: 33-44.
Bordignon, E., M.Scarzello, G.Agostini, G.Giacometti, A.Vianelli, C.Vannini and D.Carbonera (2002) Optically detected magnetic resonance of intact membranes from Chloroflexus aurantiacus. Evidence for exciton interaction between the RC and the B806-866 complex. Photosynth.Res. 71: 45-57.
Carbonera, D., E.Bordignon, G.Agostini, A.Vianelli, C.Vannini and G.Giacometti (2001) Fluorescence and absorption detected magnetic resonance of chlorosomes from green bacteria Chlorobium tepidum and Chloroflexus aurantiacus. A comparative study. J.Phys.Chem.B 105, 246-255.
Vianelli, A., G.R.Wang, M.Gingery, R.L.Duda, F.A.Eiserling and E.B.Goldberg (2000) Bacteriophage T4 Self-Assembly: Localization of gp3 and Its Role in Determining Tail Length. J.Bacteriol. 182: 680-688.
Wang, G.R., A.Vianelli and E.B.Goldberg (2000) Bacteriophage T4 Self-Assembly: In Vitro Reconstitution of Recombinant gp2 into Infectious Phage. J.Bacteriol. 182: 672-679.
Tarantino, D., A.Vianelli, L.Carraro and C.Soave (1999) A nuclear mutant of Arabidopsis thaliana selected for enhanced sensitivity to light-chill stress is altered in PS II electron transport activity. Physiol.Plant., 107, 361-371.
Vannini, C., M.Granata, M.T.Balsemin, P.D.Gerola and A.Vianelli(1998) Light intensity acclimation of the photosynthetic apparatus in Chlorobium tepidum. In: Photosynthesis: Mechanisms and Effects (G.Garab, ed.), Vol.III, 2269-2272. Kluwer Academic Publishers, Dordrecht, The Netherlands.
Carbonera, D., G.Giacometti, C.Vannini, P.D.Gerola, A.Vianelli, A.L.Maniero and L.C.Brunel (1998) Electron magnetic resonance of the chlorosomes from green sulfur bacterium Chlorobium tepidum. In: Photosynthesis: Mechanisms and Effects (G.Garab, ed.), Vol.I, 109-112. Kluwer Academic Publishers, Dordrecht, The Netherlands.
Barzda, V., I.Simidijev, A.Vianelli , R.Jennings and G.Garab (1995) Light induced reversible structural changes in chirally organed macroaggregates of purified chlorophyll a/b protein complexes. In: Photosynthesis: from Light to Biosphere (P.Mathis, ed.), Vol.I, 315-318. Kluwer Academic Publishers, Dordrecht, The Netherlands.
Finazzi, G., R.Bianchi, A.Vianelli, A.M.Ehrenheim and G.Forti (1995) Inhibition of photosystem 2 primary photochemistry by photogenerated protons. Photosynth.Res. 46, 379-392.
Jennings, R.C., G.Zucchelli, R.Bassi, A.Vianelli, and F.M.Garlaschi (1993) The relation between the minor chlorophyll spectral forms and fluorescence quenching in aggregated light harvesting chlorophyll a/b complex II. Biochim. Biophys. Acta, 1184, 279-283.
Jennings, R.C., F.M.Garlaschi, R.Bassi, G.Zucchelli, A.Vianelli and P.Dainese (1993) A study of Photosystem II fluorescenc emission in terms of the antenna chlorophyll-protein complexes. Biochim. Biophys. Acta, 1183, 194-200.
Jennings, R.C., G.Zucchelli, F.M.Garlaschi and A.Vianelli (1992) A comparison of the light-induced, non-reversible fluorescence quenching in Photosystem II with quenching due to open reaction centres in terms of the chlorophyll emission spectral forms. Biochim.Biophys.Acta 1101:79-83.
Ehrenheim, A.M., A.Vianelli, G.Finazzi and G.Forti (1992) Regulation by localized protons of Photosystem II photochemical efficiency. Biochim. Biophys. Acta, 1100, 299-302.
Forti, G. and A.Vianelli (1988) Influence of thylakoid protein phosphorylation on photosystem I photochemistry. FEBS Lett., 231, 95-98.